Panthers rookie running back Kenjon Barner will miss his second consecutive game after suffering a foot injury in the preseason, and James Dockery will also be on the inactive list after having thumb surgery a few weeks ago.
The other inactives for Carolina are: CB Melvin White, C Brian Folkerts, TE Brandon Williams, DT Sione Fua and DE Wes Horton.
Buffalo's secondary is weakened because S Jairus Byrd and CBs Ron Brooks and Stephon Gilmore will all be out due to injuries. Also on the inactive list for the Bills are: K Dustin Hopkins, C Doug Legursky, TE Chris Gragg and WR Marquise Goodwin.
Here's the bottom line: Carolina has an advantage on offense with Buffalo missing several key starters. If they want to win this game, they need to exploit that advantage.